The gorgeous Vancouver native with the smoldering blue eyes became engaged to her husband (Saturday Night Live's Taran Killam) and gave birth to their daughter, Shaelyn, in 2009.
Her hit series, How I Met Your Mother, on which she plays Canadian Robin Scherbatzky, is concluding its ninth and final season this year.
And her recurring role as S.H.I.E.L.D second-in-command Maria Hill in the Marvel movie universe (first introduced in 2012's The Avengers), has resulted in a nine-picture commitment for the 31-year-old actress, next seen as Hill in 2014's Captain America: The Winter Soldier.
"I like to only have jobs where I do it for, like, nine years," laughs Smulders. "That's the dream isn't it? It's like, just a shower of treats. I don't know why I got it, but I'm very grateful."
In Delivery Man, her current big screen role, Smulders plays Emma, the taken-for-granted girlfriend of Vince Vaughn's David Wozniak, a charming but clueless delivery driver for his family's meat company.
Little does Emma realize when she informs Wozniak she's pregnant with his child, that she's far from being the only one -- a snafu at the fertility clinic where Vaughn's character used to be a regular contributor has resulted in his being the biological father of 533 kids.
We couldn't help but ask if Smulders had encountered any David Wozniaks back in her single days.
"Oh yeah, Vancouver's full of David Wozniaks," says Smulders, not in a disparaging way. "But there's something quite charming about somebody who is able to just float through life going, 'I only need this much money to pay my rent and this much money for food and I'll just figure it out.' I'm so not like that. I get panicked. I'm sure they live longer -- it's a much more peaceful mentality."
Born Jacoba Francisca Maria Smulders to a Dutch father and an English mother (she earned the nickname, Cobie, from a great aunt), the five foot, eight-inch beauty had worked as a model before turning to acting.
One of her first film roles was in the 2004 Dwayne Johnson remake of Walking Tall, cast as a character identified as "Beautiful Eye Candy in Car."
Given that sort of typical industry chauvinism, did she experience firsthand the old Hollywood maxim that a woman who was strikingly attractive couldn't also be funny?
"Are you lopping me into that category?" she asks. "Here's the thing -- I don't perceive myself that way. Maybe I look very dressed up now, but if you catch me at home I'm in sweatpants and a T-shirt for sure, in the dirt with my child."
"The funny thing is I never actually did a comedy until How I Met Your Mother,' shares Smulders. "And you know, before that, I didn't think that I was funny. I mean, I knew that I was funny with my pals, but I didn't think I could do it on the TV! So I thought it was kind of a crazy move on their part to have me."
As for nabbing the Maria Hill role, her audition was also far from feeling like a sure thing.
"With The Avengers," she recalls, "I left that audition going, 'Well, that was fun. I didn't get it, but that was fun. Definitely did not get it!'"