Launch is scheduled for 5:17 p.m. ET
NASA flight engineers Mark Vande Hei and Joe Acaba and Russian Roscosmos cosmonaut Alexander Misurkin are scheduled to blast off from Baikonur Cosmodrome in Kazakhstan at 5:17 p.m. EDT.
After the launch, the Soyuz spacecraft will head to the International Space Station on a six-hour fast-track, scheduled to dock at 10:57 p.m.
The hatches will open around 12:40 a.m. ET on Sept. 13, where the current crew, comprised of NASA commander Randy Bresnik, and flight engineers Sergey Ryasanskiy from Roscosmos and Paolo Nespoli from the European Space Agency, will greet them.